Frankfurt was from the outset one of the most strategically and economically important crossings of the Oder. A market town grew up on the site of the original Slavic settlement from 1226 onwards; from 1250 it was part of Brandenburg, and in 1253 it was granted a charter as a town equivalent to that of Berlin. It was part of the Hanseatic League from the end of the 14th until the 15th century, and from 1506 to 1811 was a university town.
Comenius visited Frankfurt an der Oder in 1656, on his journey from Silesia to the Netherlands.